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KMID : 0377519860110010037
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Chung-Ang Journal of Medicine
1986 Volume.11 No. 1 p.37 ~ p.47
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Effects of Agents Related to Gastric Secretion on Gastric Mucosal Histamine, Gastrin and Somatostatin Concentrations in Rats
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Abstract
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Gastric mucosal histamine, gastrin and somatostatin concentrations treated with agents related´ to gastric secretion were studied in rats, using biochemical method and radioimmunoassay.
The results were as follows:
1. In pentagastrin treated group, mucosal protein and gastrin concentrations were significantly higher than control. But pH, mucosal histamine and somatostatin were significantly lower than control (p<0.005).
2. In histamine treated group, mucosal protein and somatostatin concentrations were significantly higher than control. But pH, mucosal histamine and gastrin concentrations were significantly lower than control (p<0. 005). Positive relationship between mucosal gastrin and somatostatin was observed. Also positive relationship between mucosal somatostatin and histamine concentration was observed.
3. In carbachol treated group, mucosal protein and histamine concentrations titi-ere significantly- higher than control. But mucosal somatostatin concentration was significantly lower than control (p<0.005). Inverse relationship between mucosal gastrin and histamine concentration was observed. Also inverse
1.
relationship between mucosal gastrin and somatostatin concentration was observed.
4. In somatostatin treated group, mucosal somatostatin concentration was significantly lower than control (p<0.005). But pH was significantly higher than control (p<0,005). Positive relationship between mucosal` gastrin and somatostatin concentration was observed.
1 5., In ranitidine treated group, pH, mucosal somatostatin, histamine and protein concentrations were signi- ..
[ ficantly´higher than control (p <0. 005).
6. In pirenzepiae treated group; pH, mucosal protein, gastrin and somatostatin concentrations were significantly higher than control~p<0. 005). Inverse relationship between mucosal histamine and somatostatin concentration was observed.
7. In correlation coefficients between gastric secretagogues- and inhibited materials, there were; inverse relationship of pH of gastric juice and positive relationship of mucosal somatostatin concentration between pentagastrin and somatostatin treated groups. Positive relationship of mucosal somatostatin
concentration between histamine and ranitidine treated groups. Inverse relationship of mucosal protein concentration and positive relationship of mucosal histamine concentration between carbachol and pirenzepine treated groups.
It is suggested that the pentagastrin, histamine, carbachol, somatostatin, ranitidine and pirenzepine "influence the concentration of gastrin:, somatostatin and histamine in gastric glandular mucosa of the rat, and that there is a functional interrelationships among the acid secretion, histamine, gastrin and somatostatin concentration in the mucosa of the rat.
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